AN504 Nanoparticle Specimen Preparation for Transmission Electron Microscopy

AN504 Nanoparticle Specimen Preparation for Transmission Electron Microscopy

Illustrated protocol showing the preparation of nanoparticle specimens for negative stain TEM using Formvar®-filmed grids in mPrep/g capsules. Eight different formulations of ~100 nm drug delivery particles were prepared simultaneously for a pharmaceutical company to evaluate structure and uniformity. This general sample preparation method can be applied to other nano-scale specimens including nano-fibers and viruses.

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